Saturday, February 24, 2024

What Is Cortisol Blood Test

How Does A Cortisol Test Work

Adrenal fatigue testing: Which test is best? (urinary vs salivary vs serum)

Cortisol can be measured in the blood, urine, saliva or a combination. Your healthcare provider will tell you which test they recommend for you.

  • Blood test: In an office, clinic or lab, a healthcare provider inserts a thin needle into a vein in your arm. The needle collects a small sample of blood into a tube. You might feel a slight sting when the needle goes in.
  • Saliva test: You or a healthcare provider puts a swab in your mouth and waits a few minutes until the swab is saturated with spit. If you do the test yourself at home, your healthcare provider will give you a special kit. Theyll tell you what time to perform the test and how to return the sample.
  • Urine test: Your healthcare provider gives you a container to collect your pee. Most urinary cortisol tests collect all the pee you produce in 24 hours. Your healthcare provider may ask you to store the urine in a cold place, then return it to their office or a lab.

You may need to repeat cortisol testing twice in one day or multiple times over several days because cortisol levels vary.

Low Cortisol Levels Are Suggestive Of The Following Conditions

  • Addisons Disease Adrenal glands do not produce enough cortisol
  • Hypopituitarism A disorder of the pituitary gland due to which production of cortisol by adrenals is poor

Altered cortisol levels are also often found among individuals who work in night shifts. An altered circadian cycle is also known to influence blood cortisol levels.

If blood cortisol levels are not normal, your doctor may advise some more blood, urine or radiological tests to diagnose the underlying cause for abnormal test results. A CT scan or an MRI may also be advised which will help to view the adrenal glands, pituitary gland or tumors to understand the possible causes for the abnormal secretion of cortisol.

Dr. Himanshi is a Homoeopathic consultant and currently working as a lecturer in Post-graduate faculty of Homeopathy, Parul University, Vadodara. Completed BHMS and MD in Homeopathy in January 2018 and also has a clinical experience of about 6 years. Personal interests include reading, spending time with family and traveling.

Will Lowering Cortisol Help Lose Weight

Answer From Katherine Zeratsky, R.D., L.D. There is no solid evidence that cortisol blockers lead to weight loss. When you’re under stress, your body boosts production of the hormone cortisol. Chronic stress and persistently high cortisol levels may be associated with increased appetite and weight gain.

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How To Test Cortisol Levels At Home

Cortisol can be tested in three different ways. You can use a blood test, urine test, or saliva test. Sometimes, a combination of different tests may be used.

Blood tests for cortisol are one of the most common home testing methods. This test measures the total amount of cortisol in your blood, including cortisol carried on the carrier protein cortisol binding globulin . You simply order a home test kit and collect a blood sample via a fingerprick. You send this sample to the lab, and then you get your results online in a few days.

There are also salivary tests for cortisol. The salivary cortisol test only measures free cortisol, meaning cortisol that isnt bound to the carrier protein. Studies have generally shown that theres a strong correlation between the results of a saliva test for cortisol level and a blood test for cortisol levels taken at the same time.

In some cases, a 24-hour urine collection may be used to test for cortisol. For this type of test, you collect all of your urine for an entire day. Although this method does allow for the determination of an average cortisol level over a longer period of time, its very inconvenient, and is not generally used as a home cortisol test.

Taking A Cortisol Test

Cortisol Blood Test

Cortisol can be measured in the blood, saliva, or urine. Because cortisol levels change throughout the day, your doctor will likely recommend that your cortisol test be conducted at a specific time, depending on the purpose of the test.

Blood samples for cortisol tests are most often collected early in the morning when the level of cortisol in your blood should be at its highest. The blood sample is usually taken from your arm at a medical office, hospital, or lab.

Saliva for a cortisol test may be collected at a medical office or at home. When testing for high cortisol, your doctor may instruct you on how to collect a sample of saliva late at night while you are at home.

For a cortisol urine test, you will be provided with containers and detailed instructions about how to collect all of the urine you produce in 24 hours. You will collect this urine yourself and then return it to a lab. For convenience, you may wish to choose a 24-hour period when you expect to be at home.

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When To Check Cortisol Levels

When taking a blood sample for a cortisol test, the timing of the sample is important. There is a natural variation in cortisol levels over the course of a day. In addition to this baseline variation, the body produces additional surges of cortisol whenever necessary. For example, when you feel stressed, when you exercise, or when youre sick, extra cortisol will temporarily be produced.

When you do a blood test for cortisol, its often best to check it early in the morning. Collecting your sample at this time will help to reduce the amount of variation from the extra surges of cortisol. Its important to know that, for most people, cortisol levels are actually highest in the morning. However, when you take the sample at this time, there should be minimal impact from random events that have happened, especially when you take your sample at home. Doctors sometimes recommend taking two samples: one in the morning, and the other one in the afternoon of the same day.

Can You Get A Cortisol Test At Home

Yes. Our fingerprick home health test kit tests for 21 blood markers and includes a cortisol test.

There are quite a few other cortisol test providers in the market. However, we show how your cortisol levels might affect your overall health.

For instance, cortisol affects your mood, fitness, and immunity. Its crucial to understand that our health cannot be assessed in the context of a single blood marker. At ElevateMe, we build a holistic profile of your health and wellness.

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What Is A Cortisol Test

A cortisol test measures the level of cortisol in your body. Cortisol is a hormone made by your adrenal glands. The test determines whether you have too much or too little of the hormone.

The test requires a sample of blood, urine, saliva or a combination. The results can help healthcare providers diagnose:

  • Addisons disease, also known as hypocortisolism or primary adrenal insufficiency. This condition happens when your body has too little cortisol.
  • Cushings syndrome, also called hypercortisolism. The condition occurs when your body has too much cortisol.
  • Tumor affecting the production of cortisol. Various tumors may cause high cortisol levels.

A cortisol test is sometimes called:

  • Urinary cortisol.

Are Test Results Accurate

Cortisol Test for Fatigue, Weight Change & Measure Adrenal Performance/Stress

Cortisol tests are likely to accurately reflect your cortisol level at the time the test was taken, though no test is without some potential for error.

Accurate testing requires proper sample collection, and some patients who are collecting 24-hour urine samples may find it difficult to follow collection instructions precisely. If too little or too much urine is collected, test results can be affected.

To try to get the most accurate results, a doctor will make careful selection of initial and, if needed, repeat or follow-up testing. To interpret your results, your doctor will take individual factors into account, including your symptoms, the medications you take, and your sleep schedule.

Cortisol tests are complex to interpret, so any questions about their accuracy or significance should always be addressed in consultation with a medical professional.

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What Your Cortisol Results Mean

This cortisol test is a blood test. Any blood sample taken between 8:00 am and 6:00 pm is expected to be around 23 mcg/dL. Since laboratories have different techniques to measure cortisol, normal ranges may vary slightly. If your levels are above normal then, you may have a tumor or growth on your pituitary gland that is causing it to produce high levels of ACTH. High levels may also indicate having a tumor on the adrenal gland that is causing high formation of cortisol, or a tumor anywhere else in the body that may have an interference with cortisol production.

When your cortisol levels are lower than normal this normally indicates that you either have Addison disease or Hypopituitarism. Addisonâs disease is also referred to as primary adrenal insufficiency. It is a long-term disorder of the adrenal glands that no longer produce the right amounts of steroids in the body. Hypopituitarism is a condition where the pituitary gland fails to produce enough hormones. In children, this condition may lead to dwarfism, while in adults it could lead to premature aging.

What Causes Low Levels Of Cortisol

Having lower-than-normal cortisol levels is considered adrenal insufficiency. There are two types of adrenal insufficiency: primary and secondary. The causes of adrenal insufficiency include:

  • Primary adrenal insufficiency: Primary adrenal insufficiency is most commonly caused by an autoimmune reaction in which your immune system attacks healthy cells in your adrenal glands for no known reason. This is called Addisons disease. Your adrenal glands can also become damaged from an infection or blood loss to the tissues . All of these situations limit cortisol production.
  • Secondary adrenal insufficiency: If you have an underactive pituitary gland or a pituitary tumor, it can limit ACTH production. ACTH signals your adrenal glands to make cortisol, so limited ACTH results in limited cortisol production.

You can also have lower-than-normal cortisol levels after stopping treatment with corticosteroid medications, especially if you stop taking them very quickly after a long period of use.

What are the symptoms of low cortisol levels?

Symptoms of lower-than-normal cortisol levels, or adrenal insufficiency, include:

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Common Myths About Cortisol Tests

Q. Is Cortisol the only stress hormone?

A. No. There are a total of 3: cortisol, adrenaline, and noradrenaline28.

Q. Will morning exercise affect my cortisol levels?

A. Possibly, it depends on the intensity of the exercise. Intense exercise causes an immediate spike in cortisol production. For this reason, it may be best to avoid the morning exercise session on the day of your test.

Q. Is there any medication that will affect my cortisol levels?

A. Yes. A handful of drugs alter cortisol levels in the way that they work. These include steroids29, drugs containing androgen, and phenytoin.

What Are The Symptoms Of Low Cortisol Levels

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Low levels of cortisol can cause weakness, fatigue, and low blood pressure. You may have more symptoms if you have untreated Addison’s disease or damaged adrenal glands due to severe stress, such as from a car accident or an infection. These symptoms include sudden dizziness, vomiting, and even loss of consciousness.

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Where Can I Find A Cortisol Test Near Me

Check our lab finder to locate a collection site in your area.

Note: Result turn around times are an estimate and are not guaranteed. Our reference lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.


People ordering this test on a Doctor’s recommendation should be aware of any medications they are taking which may affect Cortisol levels.

It is recommended that someone taking Biotin stop consumption at least 72 hours prior to the collection of a sample.



Questions For Your Doctor About Test Results

Your doctor is in the best position to help you understand your cortisol test results. It could be helpful to ask specific questions, such as:

  • Is this cortisol test result within the reference range?
  • What does the result of this cortisol test say about my health?
  • Are you able to make a diagnosis based on this test result?
  • Do you recommend any additional tests? Why or why not?

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What Are The Normal Values Of Cortisol In Your Body

Due to the way the body needs cortisol levels to vary throughout the day, there is no pinpoint normal number. Instead, using the time of the blood test, there is a range of normal values. This is because not every test can be done at the same time and it is, therefore, harder to compare this.

Heres a graph that shows the normal pattern of cortisol levels in black. The blue dots show the true results of healthy cortisol levels. This graph shows how these results are not completely on the curve but are still completely acceptable.

The most commonly used blood test is the morning one. At ElevateMe, we use a sample that is taken in the first 3 hours of waking up. This provides the clearest picture of cortisol levels.

According to the NHS, these levels should be between 119-618 nmol/L7. In reference to the graph above, this is equivalent to 4.31 g/dl -22.4 g/dl.

At ElevateMe, we use optimal ranges to track your blood tests in lieu of reference ranges. Reference ranges are numbers that any adult should ideally target. However, to truly thrive and live your best life, optimal ranges which are developed with the healthiest of individuals as the benchmark, are the way to go. You can learn more about the benefits of using optimal blood test ranges over reference blood test ranges here.

The optimal range for cortisol levels is between 171-535 nmol/L.

Can You Control Your Cortisol Levels With Diet

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Having a balanced diet is always essential to maintaining a healthy body.

Unhealthy food can cause an increase in cortisol production. In fact, sugar intake is a trigger for cortisol production8. If you have a regular, high intake of sugar, your cortisol levels will be constantly elevated9.

However, sugar intake can be beneficial in moments of extreme stress10. If you are facing a threat, elevated cortisol levels are exactly what you need. Interestingly, sugar can be beneficial in times of stress when the cortisol need is increased.

Unfortunately, thats one of the reasons behind stress eating. When your body detects a threat, it knows it needs more energy to be able to respond as fast as possible. This results in sugar cravings which in the long run have their own side effects.

Here is a list of foods that can be eaten at the onset of sugary cravings. Eating these instead of sugary foods will still provide your body with healthy sources of immediate energy. This will help reduce your overall cortisol levels if they are high.

  • Drinking water whilst exercising11
  • Fruits particularly bananas and pears13
  • Black tea & green tea14

Probiotics are bacteria found in yogurts. They are good for you. Prebiotics are foods that these bacterias consume. Increasing levels of both will also help reduce cortisol levels in your body15.

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What Happens During A Cortisol Test

A cortisol test often uses a sample of blood drawn at a lab. But the test may also be done on urine or saliva collected at home. Normally, cortisol levels vary during the day, so your provider may order more than one type of test to get more information about your cortisol levels.

For a blood test, a health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.

Blood samples are usually taken twice during the day–once in the morning when cortisol levels are at their highest, and again around 4 p.m., when levels are much lower.

For a cortisol urine test, your provider may ask you to collect all your urine during a 24-hour period. This is called a “24-hour urine sample test.” For this test, you’ll be given a special container and instructions for how to collect and store your urine sample. Your provider will tell you what time to start. The test usually includes the following steps:

In certain cases, a urine test for cortisol may be done on one sample of urine collected in the morning.

A cortisol saliva test is usually done at home with a kit to collect a saliva sample. Your provider will tell you what time to collect your sample. It’s often done at night before you go to bed when cortisol levels are normally lower.

What Does The Cortisol Total Test Measure

The cortisol blood test determines the level of cortisol production in the body. Cortisol is a hormone produced by the adrenal glands when stimulated by ACTH . ACTH is a hormone produced by the pituitary gland, a tiny organ inside the head below the brain.

It is released in excess amounts during stressful situations. Likewise, overproduction of cortisol also happens when problems occur in the pituitary gland, such as hyperplasia or tumor growth, causing Cushings disease.

On the other hand, low levels of cortisol can be associated with Addisons disease or adrenal insufficiency.

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What Does It Mean If You Have A High Cortisol Test Reading

High cortisol levels can point to a number of factors that you might be up against.

The most obvious reason is that you are experiencing too much stress. Consistent stress increases cortisol levels. This is due to the bodys constant readiness for a flight or fight response1.

Cortisol is produced by the adrenal glands, but the levels are controlled by another hormone called Adrenocorticotropic hormone . This hormone is made in the pituitary gland. So if either of the glands develops any tumors, whether cancerous or not, the levels of cortisol could increase1.

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