Friday, September 29, 2023

Weight Loss And Blood Pressure Medication

Your Heart And Your Life Improve

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âThe greatest gains have more to do with a lower risk of heart attack and stroke,â says James Beckerman, MD, cardiologist at the Providence St. Vincent Heart Clinic in Portland, OR.

The benefits go beyond your heart. Even a slight weight loss means more energy and the ability to do more activities. Plus, when you can do more, youâll boost your confidence and general quality of life.

Causes And Risk Factors

You may be at an increased risk for high blood pressure if you smoke, areoverweight, eat a diet thats low on produce and fiber and/or high in fatand salt, drink alcohol to excess, live with chronic stress or dont getmuch physical activity. Some causes of hypertension cannot becontrolledincluding your genes and your race . Aging also plays a role. Even if you do not have hypertensionby age 55 to 65, your lifetime risk for developing it is a whopping 90percent.

But doctors no longer consider hypertension inevitable or untreatable withage, saysSamuel Durso, M.D., director of the Division of Geriatric Medicine and Gerontology at JohnsHopkins.

In one Johns Hopkins study of 975 older women and men with hypertension,healthy lifestyle steps helped 40 percent stop taking blood pressuremedications. Other research has shown that lifestyle changes can lower therisk for hypertension in African-Americans and others at an increasedgenetic risk.

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Gaps In Research And Future Directions

With the exception of orlistat, the currently approved antiobesity drugshave not been studied well among patients with overweight/obesity andhypertension. There are no published RCTs of the short- and long-term effects ofphentermine on blood pressure, the #1 prescribed antiobesity drug, accountingfor 3 of 4 prescriptions for all drugs in this class, with > 8 millionAmericans exposed to the drug yearly. This is a major therapeutic gap and anunmet need. With the exception of naltrexone/bupropion, the currently approvedantiobesity drugs have not been tested for short- and long-term changes inambulatory blood pressure, which provides a better assessment of hypertensionthan office blood pressure alone andis superior to office-based measurements in predicting cardiovascular events andtarget organ injury . Furthermore, ABPM gathers a wealth ofinformation including 24-hr, daytime, and nighttime averages of systolic bloodpressure, diastolic blood pressure, mean arterial pressure, the degree ofnocturnal dipping, and morning surges, and the proportions of recordings withvalues higher than the established cut-off values .Therefore, an ABPM substudy should be incorporated into the portfolio of phase 2and phase 3 trials included in every new drug application of an antiobesity drugseeking FDA approval.

What Are Weight Loss Medications

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Weight loss medications, sometimes also called weight loss drugs or anti-obesity medications, are prescription drugs that reduce your appetite and food cravings. Over the last few years, the FDA has approved a number of anti-obesity medications that help control appetite and food cravings.

Because weight loss drugs make you less hungry, they also reduce how many calories your body takes in each day. Over time, eating fewer calories will cause you to lose weight.

Some anti-obesity medications also help decrease cravings and control compulsive eating, especially for sweets and fatty, salty, high-calorie foods.

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Find An Exercise Buddy

If you need help sticking with your exercise plan, ask your partner or a neighbor to walk with you. You could also make friends with someone in a group exercise class and tell them youll see them next week at the end of class. Then, youll feel accountable to show up next time. If your fittest friend is on the other side of the country, tell him/her youll send a weekly email or text sharing your weekly workouts.

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Exercise All Week Longnot Just The Weekends

You may think youre too busy to exercise for 30 minutes a day most days of the week, so youll just make up for it on the weekend. However, going gung-ho with exercise on the weekend for long periods of time may be risky for your health. Break up your exercise routine into two 15-minute sessions or even three 10-minute sessions throughout the day.

Experience Less Joint Pain

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When youre overweight or obese, the excess pounds add additional strain on your body. This is especially true for your weight-bearing joints, such as your knees and hips. For example, when it comes to your knees, every extra pound you carry translates into four additional pounds of pressure on your knees.

This means that when you lose your first 10 pounds, you alleviate 40 pounds of pressure from your knees. A similar effect results for all your weight-bearing joints, meaning you can have less overall joint pain.

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Will My Blood Pressure Be Lower If I Take Furosemide With Phentermine

Furosemide is a diuretic anti-hypertensive medication that lowers blood pressure by removing excess fluid in the blood vessels. As weight loss associated with phentermine may also lower the blood pressure, this treatment combination may cause a greater reduction in blood pressure than either medication alone. If your blood pressure decreases but remains in the normal range, your doctor may advise you to continue both treatments. However, if your blood pressure becomes abnormally low, they may advise stopping or reducing your dose of furosemide.

Can High Blood Pressure Meds Cause Weight Loss

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Lower Your Blood Pressure

When youre overweight or obese, the extra pounds you carry directly increases your blood pressure. This isnt great news for your health, since chronic high blood pressure, or hypertension, causes or contributes to more than half a million deaths each year.

The good news is that losing weight, even small amounts, can have a direct impact on lowering your blood pressure. In fact, researchers estimate that for every pound you lose, you can decrease your blood pressure by a point.

This means that after you lose your first 10 pounds, your blood pressure could drop by 10 points, which is a significant decrease. for overweight or obese patients whose weight means an elevated risk of heart disease and other cardiovascular conditions.

This means that after you lose your first 10 pounds, your blood pressure could drop by 10 points. This is a significant decrease, especially for overweight or obese patients, because carrying too many pounds can increase the risk of developing heart disease and other cardiovascular conditions.

Can You Take Phentermine And Topiramate While On Blood Pressure Pills

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Using a combination of phentermine and topiramate in addition to antihypertensive medications can increase the risk of low blood pressure. If you take Qysmia with medications for hypertension, your doctor should monitor your blood pressure before, during, and after treatment. If low blood pressure occurs, your doctor may advise reducing your dose of blood pressure pills.

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When Treatment Is Recommended

Everyone with high blood pressure is advised to make healthy lifestyle changes.

Whether medicine is also recommended depends on your blood pressure reading and your risk of developing problems such as heart attacks or strokes.

Your doctor will carry out some blood and urine tests, and ask questions about your health to determine your risk of other problems:

  • if your blood pressure is consistently above 140/90mmHg , but your risk of other problems is low you’ll be advised to make some changes to your lifestyle
  • if your blood pressure is consistently above 140/90mmHg and your risk of other problems is high you’ll be offered medicine to lower your blood pressure, in addition to lifestyle changes
  • if your blood pressure is consistently above 160/100mmHg you’ll be offered medicine to lower your blood pressure, in addition to lifestyle changes

Diuretics And Weight Loss

“Most blood-pressure-lowering medications do not result in changes in body weight,” says Gregg Fonarow, MD, director of the Ahmanson-UCLA Cardiomyopathy Center i Los Angeles.

Diuretics are an exception. This blood pressure medication does cause weight loss. Also called “water pills,” diuretics are often the first drug of choice when a person is newly diagnosed with high blood pressure. The Mayo Clinic explains that diuretics work by getting the kidneys to rid the body of salt and water. In turn, that causes blood pressure to dip by reducing the amount of fluids flowing through the veins and arteries.

“Diuretics can result in weight loss ⦠often in the range of 1 to 2 kilograms,” Dr. Fonarow says. That’s equal to roughly 2 to 4.5 pounds.

However, the downside is that diuretics â or diuretics on their own â don’t always do the trick when it comes to blood pressure control, the Mayo Clinic says. That may prompt your doctor to add another medication into the mix or withdraw diuretic treatment altogether. In the case of stopping the use of diuretics, the âEuropean Society of Cardiologyâ cautions that some patients may experience sudden weight gain due to a resulting increase in fluid retention.

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Beta Blockers And Weight Gain

On the other hand, another common blood pressure medication, beta-adrenergic blocking agents â also called beta blockers â can trigger weight gain all on their own, says Mayo Clinic.

This class of drug helps to lower blood pressure by blocking the effects of the hormone epinephrine . In doing so, these drugs â which include brands such as Sectral, Tenormin, Zebeta, Lopressor, Corgard, Bystolic and Inderal â open up the veins and arteries to improve blood flow, Mayo clinic adds. They help the heart beat more slowly and with less force, leading to a drop in blood pressure.

Mayo Clinic experts note that these drugs can cause heart-unfriendly triglyceride fat levels to rise. Though the rise is usually modest and temporary, Mayo Clinic warns that higher triglyceride levels can lead to arterial hardening and thickening, which increases the risk for cardiovascular disease.

What’s more, beta blockers are known to trigger weight gain, alongside fatigue and cold hands and feet.

Older types of beta blockers, such as Tenormin and Lopressor, are particularly problematic in that regard, Mayo Clinic notes. Typically, these medications will cause an average gain of about 2.6 pounds.

The good news is that older beta blockers are usually prescribed only when other medications fail to help lower blood pressure. Newer beta blockers â such as Coreg â are less likely to cause weight gain.

Pick Up The Pace When Walking The Dog

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Walking your dog counts as exercise, but make sure youre getting your heart rate up. If your dog is an old, slow walker, youre going to have to find a workout partner who will step up the speed with you. If you dont have a pooch, you could offer to walk a neighbors dog or accompany them on their daily outings.

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Effects Of Antiobesity Drugs On Blood Pressure Among Patients Withhypertension

Blood pressure reduction associated with weight loss is typically morepronounced in the subset of patients with hypertension. In the largest RCT of phentermine/topiramate inwhich 52% of the patients had high blood pressure or were receiving two or moreantihypertensive medications at baseline, the subgroup of hypertensive patientshad placebo-subtracted systolic and diastolic blood pressure reductions of 4.2mmHg and 1.9 mmHg, respectively, despite baseline average blood pressure notbeing very high at 133/83 mmHg.

Orlistat, approved in the US in 1999, has been the best studiedantiobesity drug among people with hypertension. A recent meta-analysis that included 4 RCTs of orlistat inpatients with hypertension estimated that the drug was associated withplacebo-adjusted systolic and diastolic blood pressure reductions of 2.5 mmHgand 1.9 mmHg, respectively. In contrast, when all randomized subjects,regardless of baseline blood pressure status, were included in anothermeta-analysis, orlistat was associated placebo-adjusted systolic and diastolicblood pressure reductions of 1.1 mmHg and 1.1 mmHg, respectively .

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Find Ways To Squeeze In 10 Minutes

You may be convinced that youre too busy to find time for exercise, but if you want to reduce or eliminate blood pressure medication, its worthwhile to find ways to be active throughout the day. Here are a few 10-minutes exercise ideas:

  • Do strength-training exercises while you watch TV. Try push-ups, crunches, lunges, squats, leg raises, or simply march in place.
  • Walk to a coffee shop or lunch spot thats at least 5 minutes away from your office. The round trip will rack up 10 minutes of exercise and reduce work stress.
  • Park your car at the end of the lot any time you run an errand. A few minutes and extra steps here and there add up.
  • Walk around your house or up and down steps any time you’re on the phone.
  • Commit to doing 10 minutes of a fitness DVD or on-demand workout. Chances are, once that time is up, youll be motivated to keep going.

Once youve carved out 10 minutes, try to find another 10, and then wake up 10 minutes earlier to work up to a total of 30 minutes every day.

Medications Used To Treat High Blood Pressure

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These high blood pressure medications flush extra water and sodium from your body. Diuretics may cause these side effects:

  • Extra urination. Extra water out means more time in the bathroom. Take these medications earlier in the day and when you’re not far away from a bathroom.
  • Erection problems in some men
  • Weakness, leg cramps, or fatigue. Diuretics may decrease the body’s levels of the mineral potassium, which can lead to these side effects. Certain potassium-sparing diuretics do not have this effect, however.
  • Intense and sudden foot pain, which is a symptom of gout this is rare.


Beta-blockers make your heart beat less forcefully and more slowly. These medications may cause side effects such as:

Angiotensin Converting Enzyme Inhibitors

These high blood pressure medications block formation of a hormone that causes blood vessels to narrow, so vessels relax. ACE inhibitors may cause these side effects:

  • A dry, hacking cough that doesn’t go away. If you have this side effect, the doctor may prescribe another type of medication.
  • Skin rash and a loss of taste are two other possible side effects of ACE inhibitors.

Angiotensin II Receptor Blockers

These high blood pressure medications shield blood vessels from a hormone that causes blood vessels to narrow. This allows blood vessels to stay open. One of the more common side effects of ARBs is dizziness.

Calcium Channel Blockers


Alpha-2 Receptor Agonist

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