Thursday, September 21, 2023

National Heart Lung And Blood Institute

Early Life And Education

The Future of the CONCERT HF Trial

Gibbons was born in , the youngest of three children born to schoolteacher parents. He grew up in the Philadelphia neighborhood of . He has credited his mother for inspiring him to be committed to public health. He received his undergraduate degree from in 1978 and later graduated from . He then completed his residency and cardiology fellowship at .

Important Events In Nhlbi History

President Harry S. Truman signed the National Heart Act, creating and establishing the National Heart Institute in the Public Health Service and the National Advisory Heart Council.

Surgeon General Leonard A. Scheele, by General Circular No. 36, Organization Order No. 14, established the NHI as one of the National Institutes of Health to assume responsibility for heart research, training, and administration as set forth in the National Heart Act. Intramural research projects in cardiovascular diseases and gerontology, conducted elsewhere in NIH, were transferred to the NHI. The director of the NHI was designated to lead and coordinate the total PHS heart program.

The National Advisory Heart Council held its first meeting. Dr. Paul Dudley White served as the Council’s Executive Director.

Cooperative research units were established at the University of California, University of Minnesota, Tulane University, and Massachusetts General Hospital. Pending completion of the NHI’s own research organization and availability of further research facilities, the units were jointly financed by the NIH and the institutions.

The NHI intramural research program was established.

The Heart Disease Epidemiology Study at Framingham, Massachusetts, was transferred from the Bureau of State Services, PHS, to the NHI.

The Clinical Center admitted its first patient for heart disease research.

The NHI was renamed the National Heart and Lung Institute , reflecting expansion of functions.

Nhlbi Nutrition Research Topics

The portfolio contained several nutrition-related research topics, demonstrated by projects containing > 1 RCDC category , which are not mutually exclusive. The top overlapping RCDC categories for newly funded extramural research projects included Cardiovascular , Prevention , Clinical Research , Obesity , Heart Disease , Behavioral and Social Science , Diabetes , Translational Research , Pediatric , Genetics , Aging , and Atherosclerosis . A smaller proportion of funded nutrition research included RCDC categories directly relevant to lung-, blood-, and sleep-related disorders. These projects included Lung , Sleep Research , Asthma , Hematology , Smoking and Health , and Tobacco . Approximately 54.9% of new grants included only human participants , 30.9% included only animals , 8.5% included neither animals nor humans , and 5.6% included both animals and humans . Of the grants, 19.8% were classified as clinical trials . highlights the subtopics for each identified RCDC category. Noteworthy is the consistency of certain topics across each RCDC category, including adipose tissue, weight loss and gain, metabolic syndrome, and fatty acids. Other less common topics included DNA methylation , plasma trimethylamine N-oxide , and oxidative stress. Vitamin D was also a consistenttopic, as well as for topics on prevention, pediatrics, genetics, and heart disease and clinical research.

Overlapping topical area .

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Evolution Of The Institution

The following data gives a quick reading on the scientific performance in the last years. The research ranking refers to the volume, impact and quality of the institution’s research output. The innovation ranking is calculated on the number of patent applications of the institution and the citations that its research output receives from patents. Finally, the societal ranking is based on the number of pages of the institution’s website and the number of backlinks and mentions from social networks.

National Heart Lung And Blood Institute Research Training Opportunities


Individual National Research Service Awards for Predoctoral and Postdoctoral Training F30 NHLBI Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral MD/PhD Fellows F31 Individual Predoctoral Fellowships to Promote Diversity in Health-Related Research F32 Individual Postdoctoral National Research Service AwardInstitutional Ruth L. Kirschstein National Research Service Awards T32 Institutional National Research Service Award T35 Short-Term Institutional Research Training GrantIndividual Career Development Awards K01 Mentored Career Development Award to Promote Faculty Diversity/Re-Entry in Bioical Research K08 Mentored Clinical Scientist Development Award K23 Mentored Patient-Oriented Research Career Development Award K24 Midcareer Investigator Award in Patient-Oriented Research K25 Mentored Quantitative Research Career Development Award K99/R00 NIH Pathway to Independence Award R25 Short-Term Training Program to Increase Diversity in Health-Related ResearchAdditional Resources

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Nhlbi Nutrition Research Portfolio Compared With The Overall Nih Nutrition Research Portfolio

There are similarities in the types of grants funded in the NHLBI research portfolio and the overall NIH portfolio. The projects in the overall NIH nutrition research portfolio consist of 69.8% R series, 10.8% K series, 8.5% F series, 4.4% U series, 4.5% P series, 0.3% T series, and 1.7% of projects with other activity codes . Similar to the NHLBI portfolio, the overall NIH portfolio funds only a small proportion of new T series grants each year. This analysis found only 4 newly awarded T series grants during this time period in the overall NIH nutrition research portfolio.

The investment in the overall extramural NIH nutrition portfolio increased from $1.00 billion in 2008 to $1.57 billion in 2019, representing a 56.5% increase. Over the past decade, NHLBI yearly investment in nutrition and nutrition-related research ranged from $136 million to $214 million , and these trends mirrored increases in the NIH investment.

National Heart, Lung, and Blood Institute and NIH nutrition research portfolio investment , fiscal years 20082019.

What Oig Recommends And Nih Comments

We recommend that NHLBI strengthen its internal controls for OTs by updating its policies and procedures to properly document its justifications for using OTs instead of traditional award instruments and to determine fairness and reasonableness of award amounts, allowability of costs, and compliance with Federal funding requirements.

In written comments on our draft report, NIH concurred with our recommendations and said that it would update its policies and procedures by November 15, 2021, to reflect our recommendations.

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National Heart Lung And Blood Institute

Scientific Director: Robert S. Balaban, Ph.D.

The mission of the NHLBI Division of Intramural Research is to perform robust scientific and clinical research leading to a better understanding of biology and clinical pathology. To attain this goal, the NHLBI DIR has a strong basic science foundation, coupled closely with innovative technology development and outstanding clinical investigators performing research both at the NIH Clinical Research Center and in partnership with local hospitals. Providing state-of-the-art training in basic, translational, and clinical research for the next generation of scientific and clinical leaders is a high priority.

This program provides opportunities for scientists and trainees to work together towards a better understanding of molecular machines, the cell, the body, and ultimately the treatment of human diseases.

The Office Of The Director

NHLBI Asthma Guidelines (Portnoy)

The Office of the Director of the National Heart, Lung, and Blood Institute provides overall strategic planning, policy guidance, program development and evaluation, and operational and administrative coordination for the Institute. Offices within the OD provide critical management and administrative support to the Institute, and are responsible for the transparent and responsible stewardship of the NHLBI budget.

The OD is the focal point of relationships with the Director of the NIH as well as with other components of the Department of Health and Human Services , other Federal agencies, Congress, professional societies, voluntary health organizations, and other public groups. The OD advises and guides the NHLBI’s key leaders on the principles, practices, laws, regulations, and policies of the Federal equal employment, affirmative action, civil rights, and minority programs.

The OD collects, develops, and disseminates information on the diseases of the heart, lung, and blood and on transfusion medicine, with an emphasis on disease prevention, and conducts and fosters educational programs for scientists and clinicians. It provides leadership in the transfer and assessment of information for the scientific community and the lay public, and establishes internal Institute policy for program and administrative operations, maintaining surveillance over their implementation.

Office of Management

Information Technology and Applications Center

The Office of Science and Technology

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Nih Interagency Pain Research Coordinating Committee

On February 13, 2012, the National Institutes of Health announced a new group of individuals assigned to research pain. This committee is composed of researchers from different organizations and will focus to “coordinate pain research activities across the federal government with the goals of stimulating pain research collaboration and providing an important avenue for public involvement” . With a committee such as this research will not be conducted by each individual organization or person but instead a collaborating group which will increase the information available. With this hopefully more pain management will be available including techniques for those with arthritis. In 2020 , American scientist and pain psychologist, was appointed as scientific member of the group.

Health Topics By The National Heart Lung And Blood Institute

The National Heart, Lung, and Blood Institute developed a tremendous national health topics site for patients, caregivers, and the public. You will find information related to heart, lung, and blood diseases, as well as information on sleep disorders. You can email, print, and share this source of information with your family and friends. The site can be found at

Take a look at some of the health topics that may be of interest:

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Jackson State University is designated as a “high research activity” institution by the Carnegie Foundation.Jackson State University | 1400 Lynch Street | Jackson, MS | 39217 | 601-979-2121Copyright 2021 | All rights reserved. | A Military-Friendly University

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National Heart Lung And Blood Institute Twin Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
First Posted : May 26, 2000Last Update Posted : March 16, 2016
Condition or disease
Cardiovascular DiseasesHeart DiseasesLung DiseasesHypertensionDiabetes MellitusObesityCoronary DiseaseMyocardial Ischemia


The World War II veteran cohort was originally examined during the 1969-1973 period at five examination centers located in Framingham, Massachusetts Davis, San Francisco, Los Angeles, California and Indianapolis, Indiana. The objective of the initial examination was to estimate the heritability of cardiovascular risk factors. Results of the first examination showed significant heritability for height, weight, relative weight, systolic and diastolic blood pressure, glucose tolerance, uric acid, hematocrit, plasma triglycerides, and forced expiratory volume but not for total plasma cholesterol or any of the lipoprotein cholesterol fractions


The study completion date listed in this record was obtained from the “End Date” entered in the Protocol Registration and Results System record.

Nhlbi Strategic Vision Mapping

National Heart Lung And Blood Institute, medical Biology, heart Failure ...

Given the 2016 release of the NHLBI Strategic Vision and the most recent available data in RePORTER, type 1 grants from fiscal years 2018 and 2019 were extracted from the larger data set for mapping to the NHLBI Strategic Vision. The 8 objectives in the NHLBI Strategic Vision include the following:

  • Understand normal biological function and resilience

  • Investigate newly discovered pathobiological mechanisms important to the onset and progression of HLBS diseases

  • Investigate factors that account for differences in health among populations

  • Identify factors that account for individual differences in pathobiology and in responses to treatments

  • Develop and optimize novel diagnostic and therapeutic strategies to prevent, treat, and cure HLBS diseases

  • Optimize clinical and implementation research to improve health and reduce disease

  • Leverage emerging opportunities in data science to open new frontiers in HLBS research

  • Further develop, diversify, and sustain a scientific workforce capable of accomplishing the NHLBI’s mission

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    Nih/national Heart Lung And Blood Institute



    The National Heart, Lung, and Blood Institute provides global leadership for a research, training, and education program to promote the prevention and treatment of heart, lung, and blood diseases and enhance the health of all individuals so that they can live longer and more fulfilling lives. The NHLBI stimulates basic discoveries about the causes of disease, enables the translation of basic discoveries into clinical practice, fosters training and mentoring of emerging scientists and physicians, and communicates research advances to the public. It creates and supports a robust, collaborative research infrastructure in partnership with private and public organizations, including academic institutions, industry, and other government agencies. The Institute collaborates with patients, families, health care professionals, scientists, professional societies, patient advocacy groups, community organizations, and the media to promote the application of research results and leverage resources to address public health needs. The NHLBI also collaborates with international organizations to help reduce the burden of heart, lung, and blood diseases worldwide.

    Please Note

    NORD’s Rare Disease Information Database is copyrighted and may not be published without the written consent of NORD.

    Ranks By Subject Areas/categories

    We have divided the scientific output of the institution into 19 large areas of knowledge and the following table shows only the ranks in different territorial domains achieved by the institution in each of the areas. For an institution to have a presence in an area, it is necessary that it exceed in the last year a minimum output threshold equivalent to twice the percentage that this area represents in the world. If you need scientific indicators on these areas visit Scopus and/or SciVal.

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    Intramural And Extramural Research

    NIH devotes 10% of its funding to research within its own facilities , and gives > 80% of its funding in to extramural researchers. Of this extramural funding, a certain percentage must be granted to small businesses under the program. As of 2011, the extramural funding consisted of about 50,000 grants to more than 325,000 researchers at more than 3000 institutions. By 2018, this rate of granting remained reasonably steady, at 47,000 grants to 2,700 organizations. In 2010, NIH spent US$10.7bn on , US$7.4bn on -related research, US$6.0bn on prevention research, US$5.8bn on cancer, and US$5.7bn on .

    National Heart Lung And Blood Institute: Social Determinants Of Health Research Fiscal Year 20082020

    Dr. Gary Gibbons on past NHLBI advances and priorities for 2021
    • Rebecca A. CampoCorrespondenceAddress correspondence to: Rebecca A. Campo, MS, PhD, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda MD 20892.

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    Notable Discoveries And Developments

    Since its inception, the NIH intramural research program has been a source of many pivotal scientific and medical discoveries. Some of these include:

    NIH Toolbox

    In September 2006, the NIH Blueprint for Neuroscience Research started a contract for the for the Assessment of Neurological and Behavioral Function to develop a set of state-of-the-art measurement tools to enhance collection of data in large cohort studies. Scientists from more than 100 institutions nationwide contributed. In September 2012, the NIH Toolbox was rolled out to the research community. NIH Toolbox assessments are based, where possible, on and adapted for testing by computer.

    Coronavirus vaccine

    The NIH partnered with in 2020 during the to develop a vaccine. The final phase of testing began on July 27 with up to 30,000 volunteers assigned to one of two groupsone receiving the vaccine and the other receiving salt water injectionsand continued until there had been approximately 100 cases of COVID-19 among the participants.

    Collaboration with Wuhan Institute of Virology

    Following the outbreak of the , NIH-funded has been the subject of controversy and increased scrutiny due to its ties to the which has been at the center of speculation since early 2020 that SARS-CoV-2 may have escaped in a lab incident. Under political pressure, the NIH withdrew funding to EcoHealth Alliance in July 2020.

    2020 42,000.0

    Historical funding

    Why Oig Did This Audit

    The National Institutes of Health’s use of “other transactions” , which are special award instruments that are generally not subject to Federal laws and regulations that apply to traditional award instruments, increased by $314 million from 2016 to 2019. The Federal Government generally uses OTs for high-risk, high-reward research and development projects. Although OTs are subject to fewer restrictions than contracts, grants, or cooperative agreements, they must be awarded and administered in a way that ensures proper stewardship of Federal funds.

    From October 1, 2016, through September 30, 2019 , the NIH National Heart, Lung, and Blood Institute awarded $84.3 million in Federal funds under 29 OTs.

    Our objective was to determine whether NHLBI complied with applicable Federal requirements for awarding and administering OTs.

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    Biographical Sketch Of Nhlbi Director Gary H Gibbons Md

    Gary H. Gibbons, M.D., is Director of the National Heart, Lung, and Blood Institute at the National Institutes of Health , where he oversees the third largest institute at the NIH, with an annual budget of more than $3 billion and a staff of 917 federal employees.

    The NHLBI provides global leadership for research, training, and education programs to promote the prevention and treatment of heart, lung, and blood diseases and enhance the health of all individuals so that they can live longer and more fulfilling lives.

    Dr. Gibbons research program is recognized for its discovery science related to cardiovascular health of minority populations. His laboratory is currently focused on discovering novel, ancestry-specific mediators of vascular disease. Prior to being named director of the NHLBI, Dr. Gibbons served as a member of the National Heart, Lung, and Blood Advisory Council from 2009-2012. He was also a member of the NHLBI Board of Extramural Experts , a working group of the NHLBAC.

    Throughout his career, Dr. Gibbons has received numerous honors, including election to the Institute of Medicine of the National Academies of Sciences selection as a Robert Wood Johnson Foundation Minority Faculty Development Awardee selection as a Pew Foundation Biomedical Scholar and recognition as an Established Investigator of the American Heart Association .

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