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Ibuprofen And Blood Pressure Medications

Ibuprofen And High Blood Pressure: A Dangerous Reaction

Combining ibuprofen and blood pressure medications might be bad for your kidneys

Use of nonsteroidal anti-inflammatory drugs is on the rise . Were talking about drugs like ibuprofen and naproxen. Such pain relievers are perceived as quite safe, since they have been available over the counter for decades. But there is growing evidence that prescription NSAIDs like celecoxib, diclofenac and meloxicam, as well as OTC ibuprofen and naproxen, can impact blood pressure. There are also concerns about heart attacks and other cardiovascular complications. The higher the dose the greater the risk, as this reader discovered.

Ibuprofen And Blood Pressure Medication: Final Verdict

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Only 12% Of Consumers Are Aware Ibuprofen May Interfere With The Cardioprotective Benefits Of Aspirin1

Ask patients about aspirin heart therapy before recommending ibuprofen

  • Your patients may not realize that their choice of OTC pain reliever may have consequences, depending on their health conditions and other therapies, including aspirin heart therapy regimen. Your guidance can help.

  • Below is a list of potential drug interactions and contraindications to consider before recommending ibuprofen. It is not a substitute for the full OTC Drug Facts label. Patients should always read and follow the product label for additional product information.

1. Coexisting medical conditions to consider before recommending OTC ibuprofen


  • Patients with cardiovascular disease are at increased risk for cardiovascular events when taking a non-aspirin NSAID such as ibuprofen or naproxen sodium2.

  • For patients on an aspirin heart therapy regimen, ibuprofen may interfere with the cardioprotective benefit of aspirin3.

Recent FDA NSAID label updates with respect to CV risks4:


  • Patients over age 60 and patients with existing GI risks who take ibuprofen or any other NSAID are at higher risk of developing serious GI toxicities such as an ulcer or bleeding.


  • Patients with renal dysfunction who take ibuprofen or other NSAIDs may develop chronic kidney disease5. NSAID-related renal adverse events may be dependent on dose and duration of therapy, and can include reduced glomerular filtration, nephritic syndrome, and chronic renal failure6.


What Painkiller Does Not Raise Blood Pressure

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As noted above, over-the-counter medications like acetaminophen are relatively safer for people with high blood pressure and those taking medications for elevated blood pressure. Other pain relievers like aspirin are also safe.

With that said, keeping an eye on your blood pressure numbers is a good idea. You can measure your blood pressure at home. Or your doctor may ask you to come in and have your blood pressure checked regularly, for example, if you have new onset hypertension and they are adjusting your blood pressure medications. Remember, high blood pressure has no symptoms and can cause health risks without you realizing it.

It is also worth noting that besides OTC painkillers, other medications used to treat common ailments like colds, flu, sinus problems, and heartburn may also contain active ingredients that can increase blood pressure. So, before you grab a bottle of an over-the-counter pain reliever or other medicine, check with your doctor if it can potentially interfere with blood pressure control.

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    Dehydration Plays A Major Role In Kidney Damage

    How Medications Like Ibuprofen Can Affect Your Blood Pressure

    Human clinical trials can take months or longer to produce results. Computer-simulated drug trials, however, are much faster. So, Prof. Layton and her team use their expertise in math and computer science to create computer-simulated drug trials, affording medical practitioners a much earlier indication of any potential drug interaction problems.

    This time around, their findings apply directly to many, many people currently taking drugs for their blood pressure. Such individuals may take an ibuprofen and have no idea they are putting their kidneys at risk.

    “Diuretics are a family of drugs that make the body hold less water,” Prof. Layton concludes. “Being dehydrated is a major factor in acute kidney injury, and then the RAS inhibitor and ibuprofen hit the kidney with this triple whammy. If you happen to be on these hypertension drugs and need a painkiller, consider acetaminophen instead.”

    The study is published in the journal Mathematical Biosciences.

    Copyright 2022 Nexstar Media Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.

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    How Can I Prevent Kidney Damage

    • If you take blood pressure medicines, you should avoid anti-inflammatories.
    • If you want to take anti-inflammatory medicines, check with your doctor or pharmacist first.
    • Only take one type of anti-inflammatory medicine at a time.
    • Take anti-inflammatories sparingly take the smallest dose you need for the shortest possible time.
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    Ibuprofen and High Blood Pressure: A Dangerous Reaction!

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    “It’s not that everyone who happens to take this combination of drugs is going to have problems,” says Anita Layton, professor of applied mathematics at Waterloo and Canada 150 Research Chair in mathematical biology and medicine, in a university release. “But the research shows it’s enough of a problem that you should exercise caution.”

    Mixing Ibuprofen Blood Pressure Meds May Damage Kidneys: Study

    Amlodipine and Ibuprofen

    May 6, 2022 — A study using computer-simulated drug trials found that people taking certain blood pressure medications along with painkillers such as ibuprofen may be risking kidney damage.

    A research team at the University of Waterloo in Ontario, Canada, conducted computer-simulated drug trials to study the interactions of diuretics and RAS inhibitors, which are often prescribed for people with high blood pressure, with ibuprofen, according to the study published in Mathematical Biosciences. Ibuprofen is sold over the counter as a pain reliever.

    In some cases, the combination of the three drugs âsignificantlyâ increased the risk of acute kidney injury — what the study called a âtriple whammy.â Using the three drugs was associated with a 31% increase in acute kidney damage compared to patients treated with two blood pressure drugs only, the study said.

    âItâs not that everyone who happens to take this combination of drugs is going to have problems,â Anita Layton, PhD, professor of applied mathematics at Waterloo, said in a news release from the university. âBut the research shows itâs enough of a problem that you should exercise caution.â

    The news release said computer-simulated drug trials can produce results faster than human clinical trials and âgive medical practitioners a head start with issues like drug complications.â

    The researchers suggested one solution: Consider taking acetaminophen instead of ibuprofen.

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